The Lo Nuestro Awards were established by Univision, to recognize the most talented performers of Latin music. The nominees and winners were selected by a voting poll conducted among program directors of Spanish-language radio stations in the United States and also based on chart performance on Billboard Latin music charts, with the results being tabulated and certified by the accounting firm Deloitte. The award included a trophy shaped like a treble clef.

1992

4th Annual May 14, 1992, at a live presentation held at the Caesars Palace in Las Vegas, Nevada. Selena performed Enamorada De Ti. She also presented an award with Ricky Martin.

Nominated: Female Regional Mexican Artist of the Year

1993

May 20, 1993, at the James L. Knight Center in Miami, Florida. Selena performed Como La Flor. Selena presented an award with Alvaro Tores.  La Mafia and Selena shared the award for Regional Mexican Album of the Year.

Won: Album of the Year: Entre a Mi Mundo
Won: Regional Mexican Song: Como La Flor
Won: Female Artist of the Year, Regional Mexican: Selena

1994

May 19, 1994, in Miami, Florida. She performed a medley of: Amor Prohibido, La Llamada and, Bidi Bidi Bom Bom.

Nominated Regional Mexican Album of the Year: Live!

Nominated Regional Mexican Song of the Year: Selena – "No Debes Jugar"

Won: Female Artist of the Year, Regional Mexican

1995

May 18, 1995, Miami, Florida. The Barrio Boyzz did a tribute to Selena, they performed a Spanish version of Boys 2 Men's, It's so hard to say goodbye. Her family accepted her awards.

Won: Female Artist of the Year, Pop: Selena
Won: Regional Mexican Album of the Year: Selena Amor Prohibido
Won: Regional Mexican Song of the Year: Selena Amor Prohibido
Won: Female Artist of the Year, Regional Mexican: Selena